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That changes the conversation

This was done by 2004.[7] As of 2010, afamelanotide was in Phase III trials for erythropoietic protoporphyria and polymorphous light eruption, and was in Phase II trials for actinic keratosis and squamous cell carcinoma, and had been trialled in phototoxicity associated with systemic photodynamic therapy and solar urticaria.[9] Clinuvel had also obtained orphan drug status for afamelanotide in the US and the EU by that time.[9] In May 2010, the Italian Medicines Agency (AIFA, or Agenzia Italiana del Farmaco) approved afamelanotide as a treatment for erythropoietic protoporphyria.[10] In January 2015, afamelanotide was approved by the European Medicines Agency (EMA) in Europe for the treatment of phototoxicity in people with EPP.[1] In October 2019, afamelanotide was approved by the US Food and Drug Administration (FDA) as a medicine to reduce pain caused by light exposure (particularly sunlight) as experienced by sufferers of erythropoietic protoporphyria.[11] Society and culture Counterfeits A number of products are sold online and in gyms and beauty salons as "melanotan" or "melanotan-1" which discuss afamelanotide in their marketing.[12][13] [14] Without a prescription the products as drugs are not legally sold in any jurisdiction and are potentially dangerous.[15][16][17][18] Starting in 2007, health agencies in various counties began issuing warnings against their use.[19][20][21][22] [23][24] See also BMS-470,539 Bremelanotide Melanotan II Methoxsalen Modimelanotide Setmelanotide References "Scenesse: Summary of Product Characteristics" (PDF)