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Del Castillo-Vaquero A, Salido GM, Gonzlez A (2010) Melatonin induces calcium release from CCK-8- and thapsigargin-sensitive cytosolic stores in pancreatic AR42J cells

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These lipid hydroperoxides are unstable and can decompose into secondary oxidative products, such as aldehydes, alkanes, and ketones, with malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) being notable for their cytotoxic and mutagenic effects [51]

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Phosphate has historically been associated with poor outcomes in patients with APAP hepatotoxicity, with early studies showing an association between low phosphate levels and increased morbidity and mortality.35 However, findings from more recent studies have led to the proposal that patients with APAP hepatotoxicity and high levels of serum phosphate have worse outcomes