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IGF-I decreased during short-term fasting and caloric and protein restriction [13]

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B12 requires active folate (5-methyltetrahydrofolate) to function properly in the methionine synthase reaction, but folate levels are often low in people with MTHFR variants

doi: 10.1210/jcem.79.5.7525636 164 HwaVTomasini-SprengerCBermejoALRosenfeldRGPlymateSR

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