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Revised: February 2026) Once-Weekly Semaglutide in Adults with Overweight or Obesity (February 10, 2021) Oral Semaglutide at a Dose of 25 mg in Adults with Overweight or Obesity (September 18, 2025) Wegovy (semaglutide) Medication Guide (February 2026)

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Professor Ngs research contributions to AOD-9604 development include: Synthesis and characterization of the modified C-terminal growth hormone fragment with enhanced stability Design of the tyrosine N-terminal modification to improve peptide stability and half-life Preclinical studies demonstrating lipolytic effects in obese animal models Advancement of the peptide through multiple phases of clinical development Investigation of mechanisms underlying beta-3-adrenergic receptor modulation His work established the foundation for understanding peptide-based approaches to metabolic regulation, though clinical translation ultimately proved unsuccessful

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