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Improved biological activity of Gly^ 2-and Ser^ 2-substituted analogues of glucose-dependent insulinotrophic polypeptide
It occurs when nociceptive neurons, especially those in the dorsal horn of the spinal cord, alter how they process input, such that typical touch or mild signals become painful
Marks ability to investigate the matter further was, however, temporarily delayed by the fact that shortly after the conference Samols went to Seattle to spend a sabbatical year with Robert Williams to learn more about the clinical and laboratory aspects of diabetes (Marks 2018)
Scientific References EBioMedicine, 2024 GLP-1 receptors in brain reward circuits and desire Kinsey Institute, 2025 Survey of 2,000 adults on GLP-1 sexual desire effects International Journal of Impotence Research, 2025 FDA adverse events GLP-1 sexual dysfunction Journal of Sexual Medicine, 2025 Serotonin 5-HT2C pathway and libido on GLP-1s
