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The patients at highest risk were those on higher doses, those with pre-existing borderline B12 levels, those with a history of metformin use (which independently depletes B12), and those over age 60

[DOI] [PubMed] [Google Scholar] 187.Stupnisek M., Franjic S., Drmic D., Hrelec M., Kolenc D., Radic B., Bojic D., Vcev A., Seiwerth S., Sikiric P

The pleiotropic effects of sodium-glucose cotransporter-2 inhibitors: beyond the glycemic benefit

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However, the patient has to accept that there is no simple therapy allowing permanent cure