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Alzheimers Dement 17(1):115124 Aronne LJ et al (2024) Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity: the SURMOUNT-4 randomized clinical trial

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While this cleavage impairs the ability of cells to degrade misfolded proteins, the resulting fragments also compromise host defense by losing the ability to activate the NFB pathway (167)

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Dosing and PK/PD alignment Select route and schedule that achieve sustained receptor activation within an acceptable tolerability window