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Considering the growing body of evidence demonstrating the ability of leptin to stimulate cancer cell growth, promote a pro-inflammatory TME, and support the development of metastasis, together with the fact that obesogens increase leptin expression and its circulating levels, indicates that this pathway may represent a key indirect mechanism by which obesogenic exposure stimulates the development and aggressiveness of PCa

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Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life

Abstract Despite the strong immune-modulatory benefits, there has been a lag in using glucagon-like peptide-1 receptor agonists (GLP-1RAs) in rheumatoid arthritis (RA) due to inefficient articular delivery and poorly understood direct cartilage protection