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More receptor activation in the stomach and intestines means slower stomach emptying, which is already the primary mechanism of action

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The upregulation of the glial fibrillary acidic protein (GFAP) was also observed in cultured astrocytes grown at high hydrostatic pressure

It releases free fatty acids and other pro-inflammatory molecules, which get into the liver and other organs and cause organ dysfunction, explains David Kessler, MD, former commissioner of the US Food and Drug Administration and author of the new book Diet, Drugs, and Dopamine

The most frequently reported side effects are gastrointestinal upset and headache