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Description

Tirzepatide acts on two receptors (GLP-1 and GIP), while semaglutide targets only GLP-1, which may explain tirzepatide's typically greater weight loss results

The placebo (withdrawal) group regained 6.9 percentage points of body weight over those 48 weeks, while the continuation group lost an additional 7.9 percentage points

It can be acute or chronic and can lead to CKD if not managed properly

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