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31 These variants are additionally proposed to result in a more robust de novo thymidylate biosynthesis as a consequence of declining amounts of 5,10-methyleneTHF being available for irreversible reduction to 5-methylTHF via action of the MTHFR enzyme

The mass spectrometer was operated in positive, data-dependent acquisition mode, initiating with a full MS scan across an m/z range of 3002000 at a resolution of 75,000

[,] SFN has demonstrated its ability to inhibit carcinogenesis through various mechanisms (Figure 7)

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