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As an anticipatory response to awakening, the highest cortisol production occurs in the second half of the night with peak cortisol values in the early morning 12,59,60,61,62

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Vitamin B12, also known as cobalamin, is a water-soluble vitamin essential for: Red blood cell formation Nervous system health DNA synthesis Brain function Energy metabolism A lack of vitamin B12 can lead to symptoms such as fatigue, depression, and memory problems, and if left untreated, it may even cause lasting neurological damage