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1A) had been reported to potentiate GLP-1R-mediated cAMP signaling in response to weak peptidic agonists, including the GLP-1 metabolite GLP-1(936)amide ( 21 ) and the GLP-1R/glucagon-receptor dual agonist oxyntomodulin ( 22 )

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All combination data comes from anecdotal clinical observations or theoretical synergy based on separate mechanisms

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The relative risk came in at 3.66, with a 95% confidence interval of 1.09 to 12.25 and a p-value of 0.036