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In various types of cancers, including gastric (5), lung (27), breast (17,28), endometrial (29), cervical (30), prostate (31) and head and neck tumors (21), the downregulation or complete silencing of GPX3 gene expression, along with hypermethylation of CpG in the CpG island of the GPX3 promoter, have been observed (32)

However, major expert groups have looked at the research and concluded that: The evidence is not sufficient to show that screening every adult without symptoms for vitamin D deficiency clearly improves outcomes such as fractures, heart disease or cancer

Extrapolation of these findings to the context of Down syndrome Our results, supported by others in mouse models (Tlili et al., 2013

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