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You can run continuous sermorelin cycles for up to 6 months without mandatory breaks, but many practitioners recommend a 30-day washout period after 46 months to prevent receptor downregulation and restore GHRH sensitivity

Therefore, in reference to the ILEP recommendations [2], the authors of these guidelines point to the need of possibly optimum non-pharmacological management (lifestyle modification), and in case of failure (unfortunately, this may apply to up to 80% of individuals) [152], after not more than 6 months, to consider initiation of pharmacological treatment, i.e

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