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doi: 10.1080/10408360701713104 7 MerkoferMKissnerRHiderRCBrunkUTKoppenolWH

Mechanistically, the sustained elevation in venous return imposes chronic diastolic wall tension, triggering elongation of sarcomeresthe fundamental contractile units of cardiomyocytesalong the longitudinal axis

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However, the comparison of NNT across various drug classes must be nuanced given the NNT values are specific to individual trial design, study population baseline characteristics, and the time of outcome measurement

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