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Chakrabandhu K, Hrincs Z, Huault S, Dost B, Peng L, Conchonaud F, Marguet D, He HT, Hueber AO

Pharmacotherapy Most patients will require oral hypoglycemic agents and/or insulin to control hyperglycemia, especially in advanced stages of liver disease

Importantly, tirzepatide's glucose-dependent mechanism means insulin secretion occurs primarily when blood glucose is elevated, substantially reducing hypoglycemia risk compared to sulfonylureas or insulin

Anamorelin also has been studied in cancer cachexia for maintaining body weight and lean mass