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A GLP-1/GIP dual receptor agonist DA4-JC effectively attenuates cognitive impairment and pathology in the APP/PS1/Tau model of alzheimers disease

At 12mg, it was 18.2%

Recent studies have also demonstrated that exendin-4 is mediated by Ca 2+ /calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/prolactin regulatory element binding (CaMKK/CaMKIV/PREB) pathway increases liver ABCA1 expression and reduces cholesterol accumulation [71]

They bind to the same receptors in the pancreas and brain to lower blood sugar and suppress appetite

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