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Model Systems and Biological Factors The type of model system being used whether its an in vitro setup or an animal model significantly impacts dosing

Medication discontinuation : If topiramate needs to be stopped, it should be gradually tapered rather than abruptly discontinued to reduce the risk of seizures, even in patients without epilepsy

Metabolic and cardiovascular benefits of GLP-1 agonists, besides the hypoglycemic effect (Review)

Cell Metab (2022) 34(2):256268.e5

It is specifically designed to allow the body to acclimate to the medication, which significantly reduces the incidence and severity of GI side effects