Factors that may trigger perioral dermatitis include the following: Drugs: steroid creams, ointments, and inhalers Fluorinated toothpaste Skincare lotions and creams, especially those containing petroleum jelly, paraffin base, and isopropyl myristate Sunscreens Makeup products Certain scented skincare products Ultraviolet (UV) light Heat Dust Wind Certain infections Oral contraceptives Hormones Vitamin B12 deficiency What are the signs of perioral dermatitis
NHS approach to B12 deficiency: NICE Clinical Knowledge Summaries recommend investigating B12 deficiency in patients presenting with macrocytic anaemia, unexplained neurological symptoms, or risk factors including pernicious anaemia, gastrectomy, malabsorption disorders, metformin use, proton pump inhibitors, or nitrous oxide exposure
Simultaneously, nicotinamide is consumed reducing the substrate available for the salvage pathway to regenerate NAD+
The study extended the AOD-9604 research agenda beyond adipose-tissue metabolism into musculoskeletal applications, an area of growing interest in the peptide research literature
Activation of this pathway is associated with hair growth initiation
