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However, patients on oral semaglutide report a slightly different timing of GI symptoms because the medication is delivered daily rather than weekly: Injectable semaglutide: peak GI effects occur in the 24 to 48 hours following the weekly dose, then diminish for the rest of the week

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Freezing is listed as not recommended because it can damage the peptide structure, and the storage table says to keep the medication above 2 degrees Celsius

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Am J Physiol 228:689692 Stumpf DA, McAfee J, Parks JK, Eguren L (1980) Propionate inhibition of succinate:CoA ligase (GDP) and the citric acid cycle in mitochondria